Regulation of REGγ cellular distribution and function by SUMO modification

Regulation of Protein Function by SUMO Modification

SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e...

Regulation and function of SUMO modification.

Regulation of HSF1 by stress-induced SUMO-1 modification

Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock protein (hsp) gene expression in cells exposed to elevated temperature and other stress conditions. In response to stress HSF1 acquires DNA-binding ability and localizes to nuclear stress granules, but the molecular mechanisms which mediate these events are not understood. We report that HSF1 undergoes stress-induced ...

Regulation of aPKC activity by Nup358 dependent SUMO modification

Atypical PKC (aPKC) family members are involved in regulation of diverse cellular processes, including cell polarization. aPKCs are known to be activated by phosphorylation of specific threonine residues in the activation loop and turn motif. They can also be stimulated by interaction with Cdc42~GTP-Par6 complex. Here we report that PKCζ, a member of the aPKC family, is activated by SUMOylation...

Protein modification by SUMO.

Small ubiquitin-related modifier (SUMO) family proteins function by becoming covalently attached to other proteins as post-translational modifications. SUMO modifies many proteins that participate in diverse cellular processes, including transcriptional regulation, nuclear transport, maintenance of genome integrity, and signal transduction. Reversible attachment of SUMO is controlled by an enzy...